The small non-coding RNAs include various classes of regulatory RNAs, of which, microRNAs are the best studied. This study, however compared young with middle aged people and no attempts were made to study extreme longevity 6. One report analysed the whole human microRNome. However, to our knowledge few studies have dealt with the regulation of RNA expression. Some recent studies have searched of mutations (especially single nucleotide polymorphisms) that may be characteristic of human extreme longevity 3, 4, 5. Our aim was to determine the molecular mechanisms by which centenarians maintain a highly efficient homeostasis. They show a remarkable compression of age associated morbidity to such an extent that their health span approximates their life span 1.Ī classical characteristic of (unsuccessful) ageing is that homeostatic, regulatory mechanisms are impaired or even lost 2. The study of centenarians is important not only because they reach a very old age but also because they are an example of successful ageing. We suggest that the small non-coding RNAs signature in centenarians may provide insights into the underlying molecular mechanisms endowing centenarians with extreme longevity. Principal Component Analysis of the expression of 15,644 mature microRNAs and, 2,334 snoRNAs and scaRNAs in centenarians revealed a significant overlap with profiles in young individuals but not with octogenarians and a significant up-regulation of 7 small non-coding RNAs in centenarians compared to young persons and notably 102 small non-coding RNAs when compared with octogenarians. We report the first comparison of microRNAs expression profiles in mononuclear cells from centenarians, octogenarians and young individuals resident near Valencia, Spain. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations in small non-coding RNA expression. They have a unique capacity to maintain homeostatic mechanisms. Centenarians exhibit extreme longevity and a remarkable compression of morbidity.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |